Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114,V804M]' and Ligand = 'BDBM305355'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114,V804M] (Homo sapiens (Human))	BDBM305355 (US10144734, Example 371 | US10172845, Example 371 ...) Show SMILES CCOc1cc(-c2ccc(nc2)N2CCC(C)(CC2)S(=O)(=O)CC(C)C)c2c(cnn2c1)C#N Show InChI InChI=1S/C25H31N5O3S/c1-5-33-21-12-22(24-20(13-26)15-28-30(24)16-21)19-6-7-23(27-14-19)29-10-8-25(4,9-11-29)34(31,32)17-18(2)3/h6-7,12,14-16,18H,5,8-11,17H2,1-4H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.20	n/a	n/a	n/a	n/a	n/a	n/a
Array Biopharma Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK assay techn...				US Patent US10441581 (2019) BindingDB Entry DOI: 10.7270/Q2DZ0BP3
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114,V804M] (Homo sapiens (Human))	BDBM305355 (US10144734, Example 371 | US10172845, Example 371 ...) Show SMILES CCOc1cc(-c2ccc(nc2)N2CCC(C)(CC2)S(=O)(=O)CC(C)C)c2c(cnn2c1)C#N Show InChI InChI=1S/C25H31N5O3S/c1-5-33-21-12-22(24-20(13-26)15-28-30(24)16-21)19-6-7-23(27-14-19)29-10-8-25(4,9-11-29)34(31,32)17-18(2)3/h6-7,12,14-16,18H,5,8-11,17H2,1-4H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	19.7	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK assay tech...				US Patent US10172845 (2019) BindingDB Entry DOI: 10.7270/Q2M90BR9
					More data for this Ligand-Target Pair