BindingDB PrimarySearch

Found 5 hits Enz. Inhib. hit(s) with Target = 'Purine nucleoside phosphorylase' and Ligand = 'BDBM50048044'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Purine nucleoside phosphorylase (Bos taurus (bovine))	BDBM50048044 (2-Amino-7-(tetrahydro-thiophen-2-ylmethyl)-3,5-dih...) Show SMILES Nc1nc2c(CC3CCCS3)c[nH]c2c(=O)[nH]1 Show InChI	PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Michigan Curated by ChEMBL					Assay Description Inhibitory activity against calf spleen purine nucleoside phosphorylase (PNP) using 2-amino-6-mercapto-7-methyl purine ribonucleoside (MESG) as subst...				J Med Chem 42: 2422-31 (1999) Article DOI: 10.1021/jm990037y BindingDB Entry DOI: 10.7270/Q2CR5SKN
University of Michigan Curated by ChEMBL					More data for this Ligand-Target Pair
Purine nucleoside phosphorylase (Bos taurus (bovine))	BDBM50048044 (2-Amino-7-(tetrahydro-thiophen-2-ylmethyl)-3,5-dih...) Show SMILES Nc1nc2c(CC3CCCS3)c[nH]c2c(=O)[nH]1 Show InChI	PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	8.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Michigan Curated by ChEMBL					Assay Description Inhibitory activity against calf spleen purine nucleoside phosphorylase (PNP) using inosine as substrate at a concentration of 10 uM.				J Med Chem 42: 2422-31 (1999) Article DOI: 10.1021/jm990037y BindingDB Entry DOI: 10.7270/Q2CR5SKN
University of Michigan Curated by ChEMBL					More data for this Ligand-Target Pair
Purine nucleoside phosphorylase (Bos taurus (bovine))	BDBM50048044 (2-Amino-7-(tetrahydro-thiophen-2-ylmethyl)-3,5-dih...) Show SMILES Nc1nc2c(CC3CCCS3)c[nH]c2c(=O)[nH]1 Show InChI	PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
BioCryst Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description In vitro inhibition of purine nucleoside phosphorylase from calf spleen in 1 mM phosphate				J Med Chem 36: 1847-54 (1993) BindingDB Entry DOI: 10.7270/Q2WQ02WD
BioCryst Pharmaceuticals, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Purine nucleoside phosphorylase (Bos taurus (bovine))	BDBM50048044 (2-Amino-7-(tetrahydro-thiophen-2-ylmethyl)-3,5-dih...) Show SMILES Nc1nc2c(CC3CCCS3)c[nH]c2c(=O)[nH]1 Show InChI	PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	17.4	n/a	n/a	n/a	n/a	n/a	n/a
University of Michigan Curated by ChEMBL					Assay Description Inhibitory activity against calf spleen purine nucleoside phosphorylase (PNP) using inosine as substrate at a concentration of 10 uM.				J Med Chem 42: 2422-31 (1999) Article DOI: 10.1021/jm990037y BindingDB Entry DOI: 10.7270/Q2CR5SKN
University of Michigan Curated by ChEMBL					More data for this Ligand-Target Pair
Purine nucleoside phosphorylase (Bos taurus (bovine))	BDBM50048044 (2-Amino-7-(tetrahydro-thiophen-2-ylmethyl)-3,5-dih...) Show SMILES Nc1nc2c(CC3CCCS3)c[nH]c2c(=O)[nH]1 Show InChI	PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	220	n/a	n/a	n/a	n/a	n/a	n/a
BioCryst Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of purine nucleoside phosphorylase from calf spleen in 50 mM phosphate				J Med Chem 36: 1847-54 (1993) BindingDB Entry DOI: 10.7270/Q2WQ02WD
BioCryst Pharmaceuticals, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair