Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'RAC-alpha serine/threonine-protein kinase' and Ligand = 'BDBM24885'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM24885 (2,3,5-trisubstituted pyridine, 10a | 5-{5-phenyl-6...) Show SMILES Nc1nnc(s1)-c1cnc(-c2ccc(CN3CCC(CC3)c3cc(n[nH]3)-c3ccncc3)cc2)c(c1)-c1ccccc1 Show InChI InChI=1S/C33H30N8S/c34-33-40-39-32(42-33)27-18-28(23-4-2-1-3-5-23)31(36-20-27)26-8-6-22(7-9-26)21-41-16-12-25(13-17-41)30-19-29(37-38-30)24-10-14-35-15-11-24/h1-11,14-15,18-20,25H,12-13,16-17,21H2,(H2,34,40)(H,37,38)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	123	n/a	n/a	n/a	n/a	7.5	22
Merck Research Laboratories					Assay Description Purified recombinant human Akt kinase was monitored for kinase activity in the presence or absence of inhibitors in a 96-well format. Detection was d...				Bioorg Med Chem Lett 18: 2194-7 (2008) Article DOI: 10.1016/j.bmcl.2007.12.040 BindingDB Entry DOI: 10.7270/Q2BG2M8B
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