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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'RAC-alpha serine/threonine-protein kinase' and Ligand = 'BDBM50312930'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM50312930
PNG
((S)-N1-(5-(3-aminobenzo[d]isoxazol-5-yl)thiazol-2-...)
Show SMILES N[C@H](CNc1ncc(s1)-c1ccc2onc(N)c2c1)Cc1ccc(cc1)C(F)(F)F |r|
Show InChI InChI=1S/C20H18F3N5OS/c21-20(22,23)13-4-1-11(2-5-13)7-14(24)9-26-19-27-10-17(30-19)12-3-6-16-15(8-12)18(25)28-29-16/h1-6,8,10,14H,7,9,24H2,(H2,25,28)(H,26,27)/t14-/m0/s1
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n/an/a 453n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human AKT1 in human U87MG cells assessed as PRAS40 phosphorylation after 1 hr by ELISA

Bioorg Med Chem Lett 20: 1559-64 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.067
BindingDB Entry DOI: 10.7270/Q20C4VWX
More data for this
Ligand-Target Pair