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Found 1 hit Enz. Inhib. hit(s) with Target = 'RAC-alpha serine/threonine-protein kinase' and Ligand = 'BDBM50347969'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM50347969
PNG
(CHEMBL1800389)
Show SMILES [#6]-[#6]-[#6]-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6]-[#7](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#6@@H](-[#7])-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccc(-[#8])cc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6](-[#6])-[#6])-[#6](=O)-[#7](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6]-[#6](-[#7])=O |r|
Show InChI InChI=1S/C48H88N18O9/c1-4-11-34(61-42(71)35(13-10-23-59-48(56)57)60-40(69)29-66(25-8-6-21-50)45(74)33(52)12-9-22-58-47(54)55)41(70)63-37(26-31-15-17-32(67)18-16-31)43(72)64-38(27-51)44(73)62-36(19-14-30(2)3)46(75)65(28-39(53)68)24-7-5-20-49/h15-18,30,33-38,67H,4-14,19-29,49-52H2,1-3H3,(H2,53,68)(H,60,69)(H,61,71)(H,62,73)(H,63,70)(H,64,72)(H4,54,55,58)(H4,56,57,59)/t33-,34-,35-,36-,37-,38-/m0/s1
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 130n/an/an/an/an/an/a



The Hebrew University of Jerusalem

Curated by ChEMBL


Assay Description
Inhibition of Akt using RPRTSSF peptide and [gamma32]ATP by cell-free radioactive assay


J Med Chem 54: 5154-64 (2011)


Article DOI: 10.1021/jm2003969
BindingDB Entry DOI: 10.7270/Q26D5TBX
More data for this
Ligand-Target Pair