Compile Data Set for Download or QSAR

Found 5 hits Enz. Inhib. hit(s) with Target = 'RAC-alpha serine/threonine-protein kinase' and Ligand = 'BDBM50536170'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50536170 (CHEMBL4544109) Show SMILES Cl.Nc1ncccc1-c1nc2ccc(nc2n1-c1ccc(cc1)C1(N)CCC1)-c1cccnc1 Show InChI InChI=1S/C26H23N7/c27-23-20(5-2-15-30-23)24-32-22-11-10-21(17-4-1-14-29-16-17)31-25(22)33(24)19-8-6-18(7-9-19)26(28)12-3-13-26/h1-2,4-11,14-16H,3,12-13,28H2,(H2,27,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
ArQule Inc. Curated by ChEMBL					Assay Description Inhibition of full length unphosphorylated AKT1 (1 to 480 residues) (unknown origin) expressed in baculovirus infected Sf9 insect cells using biotin-...				J Med Chem 59: 6455-69 (2016) Article DOI: 10.1021/acs.jmedchem.6b00619 BindingDB Entry DOI: 10.7270/Q2RN3CCM
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50536170 (CHEMBL4544109) Show SMILES Cl.Nc1ncccc1-c1nc2ccc(nc2n1-c1ccc(cc1)C1(N)CCC1)-c1cccnc1 Show InChI InChI=1S/C26H23N7/c27-23-20(5-2-15-30-23)24-32-22-11-10-21(17-4-1-14-29-16-17)31-25(22)33(24)19-8-6-18(7-9-19)26(28)12-3-13-26/h1-2,4-11,14-16H,3,12-13,28H2,(H2,27,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	34	n/a	n/a	n/a	n/a	n/a	n/a
ArQule Inc. Curated by ChEMBL					Assay Description Inhibition of full length active AKT1 (1 to 480 residues) (unknown origin) expressed in baculovirus infected Sf9 insect cells using biotin-GRPRTSSFAE...				J Med Chem 59: 6455-69 (2016) Article DOI: 10.1021/acs.jmedchem.6b00619 BindingDB Entry DOI: 10.7270/Q2RN3CCM
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50536170 (CHEMBL4544109) Show SMILES Cl.Nc1ncccc1-c1nc2ccc(nc2n1-c1ccc(cc1)C1(N)CCC1)-c1cccnc1 Show InChI InChI=1S/C26H23N7/c27-23-20(5-2-15-30-23)24-32-22-11-10-21(17-4-1-14-29-16-17)31-25(22)33(24)19-8-6-18(7-9-19)26(28)12-3-13-26/h1-2,4-11,14-16H,3,12-13,28H2,(H2,27,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	56	n/a	n/a	n/a	n/a	n/a	n/a
ArQule Inc. Curated by ChEMBL					Assay Description Inhibition of AKT1 phosphorylation at Ser473 in EGF/insulin-stimulated human AN3CA cells incubated for 1 hr followed by stimulation for 15 mins by We...				J Med Chem 59: 6455-69 (2016) Article DOI: 10.1021/acs.jmedchem.6b00619 BindingDB Entry DOI: 10.7270/Q2RN3CCM
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50536170 (CHEMBL4544109) Show SMILES Cl.Nc1ncccc1-c1nc2ccc(nc2n1-c1ccc(cc1)C1(N)CCC1)-c1cccnc1 Show InChI InChI=1S/C26H23N7/c27-23-20(5-2-15-30-23)24-32-22-11-10-21(17-4-1-14-29-16-17)31-25(22)33(24)19-8-6-18(7-9-19)26(28)12-3-13-26/h1-2,4-11,14-16H,3,12-13,28H2,(H2,27,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	63	n/a	n/a	n/a	n/a	n/a	n/a
ArQule Inc. Curated by ChEMBL					Assay Description Inhibition of AKT1 phosphorylation at Thr308 in EGF/insulin-stimulated human AN3CA cells incubated for 1 hr followed by stimulation for 15 mins by We...				J Med Chem 59: 6455-69 (2016) Article DOI: 10.1021/acs.jmedchem.6b00619 BindingDB Entry DOI: 10.7270/Q2RN3CCM
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50536170 (CHEMBL4544109) Show SMILES Cl.Nc1ncccc1-c1nc2ccc(nc2n1-c1ccc(cc1)C1(N)CCC1)-c1cccnc1 Show InChI InChI=1S/C26H23N7/c27-23-20(5-2-15-30-23)24-32-22-11-10-21(17-4-1-14-29-16-17)31-25(22)33(24)19-8-6-18(7-9-19)26(28)12-3-13-26/h1-2,4-11,14-16H,3,12-13,28H2,(H2,27,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	640	n/a	n/a	n/a	n/a	n/a	n/a
ArQule Inc. Curated by ChEMBL					Assay Description Inhibition of AKT1 in EGF/insulin-stimulated human AN3CA cells assessed as reduction in phosphorylation at Thr246 incubated for 1 hr followed by stim...				J Med Chem 59: 6455-69 (2016) Article DOI: 10.1021/acs.jmedchem.6b00619 BindingDB Entry DOI: 10.7270/Q2RN3CCM
					More data for this Ligand-Target Pair