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Found 1 hit Enz. Inhib. hit(s) with Target = 'RAC-gamma serine/threonine-protein kinase' and Ligand = 'BDBM50398371'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
RAC-gamma serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM50398371
PNG
(CHEMBL2177363)
Show SMILES C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(CC3)C(=O)[C@H](CN3CCC(F)CC3)c3ccc(Cl)cc3)c12 |r|
Show InChI InChI=1S/C26H33ClFN5O2/c1-17-14-22(34)24-23(17)25(30-16-29-24)32-10-12-33(13-11-32)26(35)21(18-2-4-19(27)5-3-18)15-31-8-6-20(28)7-9-31/h2-5,16-17,20-22,34H,6-15H2,1H3/t17-,21-,22-/m1/s1
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n/an/a 10n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt3 expressed in recombinant baculovirus system using fluo...

J Med Chem 55: 8110-27 (2012)


Article DOI: 10.1021/jm301024w
BindingDB Entry DOI: 10.7270/Q20P1160
More data for this
Ligand-Target Pair