Compile Data Set for Download or QSAR

Found 4 hits Enz. Inhib. hit(s) with Target = 'RAF proto-oncogene serine/threonine-protein kinase' and Ligand = 'BDBM202695'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens (Human))	BDBM202695 (US10245267, Example 40 | US10709712, Example 40 | ...) Show SMILES Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1cc(nc(OCCO)n1)N1CCOCC1 Show InChI InChI=1S/C25H25F3N4O4/c1-16-5-6-19(29-23(34)17-3-2-4-18(13-17)25(26,27)28)14-20(16)21-15-22(32-7-10-35-11-8-32)31-24(30-21)36-12-9-33/h2-6,13-15,33H,7-12H2,1H3,(H,29,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.132	n/a	n/a	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description C-Raf TR refers to a truncated C-Raf protein, a Δ1-324 deletion mutant.C-Raf FL refers to the full-length C-Raf protein.Full length MEK1 with an...				US Patent US10709712 (2020) BindingDB Entry DOI: 10.7270/Q2280BP3
					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens (Human))	BDBM202695 (US10245267, Example 40 | US10709712, Example 40 | ...) Show SMILES Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1cc(nc(OCCO)n1)N1CCOCC1 Show InChI InChI=1S/C25H25F3N4O4/c1-16-5-6-19(29-23(34)17-3-2-4-18(13-17)25(26,27)28)14-20(16)21-15-22(32-7-10-35-11-8-32)31-24(30-21)36-12-9-33/h2-6,13-15,33H,7-12H2,1H3,(H,29,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.132	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description Raf and biotinylated Mek, kinase dead, were combined at 2× final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...				Bioorg Med Chem Lett 17: 5115-20 (2007) BindingDB Entry DOI: 10.7270/Q2RB76WP
					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens (Human))	BDBM202695 (US10245267, Example 40 | US10709712, Example 40 | ...) Show SMILES Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1cc(nc(OCCO)n1)N1CCOCC1 Show InChI InChI=1S/C25H25F3N4O4/c1-16-5-6-19(29-23(34)17-3-2-4-18(13-17)25(26,27)28)14-20(16)21-15-22(32-7-10-35-11-8-32)31-24(30-21)36-12-9-33/h2-6,13-15,33H,7-12H2,1H3,(H,29,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description C-Raf TR refers to a truncated C-Raf protein, a Δ1-324 deletion mutant.C-Raf FL refers to the full-length C-Raf protein.Full length MEK1 with an...				US Patent US10709712 (2020) BindingDB Entry DOI: 10.7270/Q2280BP3
					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens (Human))	BDBM202695 (US10245267, Example 40 | US10709712, Example 40 | ...) Show SMILES Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1cc(nc(OCCO)n1)N1CCOCC1 Show InChI InChI=1S/C25H25F3N4O4/c1-16-5-6-19(29-23(34)17-3-2-4-18(13-17)25(26,27)28)14-20(16)21-15-22(32-7-10-35-11-8-32)31-24(30-21)36-12-9-33/h2-6,13-15,33H,7-12H2,1H3,(H,29,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description Raf and biotinylated Mek, kinase dead, were combined at 2× final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...				Bioorg Med Chem Lett 17: 5115-20 (2007) BindingDB Entry DOI: 10.7270/Q2RB76WP
					More data for this Ligand-Target Pair