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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'RAF proto-oncogene serine/threonine-protein kinase [306-648,Y340D,Y341D]' and Ligand = 'BDBM210018'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
RAF proto-oncogene serine/threonine-protein kinase [306-648,Y340D,Y341D]


(Homo sapiens (Human))		BDBM210018
PNG
(US10576087, Compound 2.24 | US9273046, 2.24 | US98...)
Show SMILES Cn1c(nc2cc(ccc12)C(F)(F)F)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12
Show InChI InChI=1S/C26H19F3N4O3/c1-33-17-5-2-12(26(27,28)29)10-16(17)31-25(33)22-21-15-11-13(3-6-18(15)36-23(21)22)35-19-8-9-30-24-14(19)4-7-20(34)32-24/h2-3,5-6,8-11,21-23H,4,7H2,1H3,(H,30,32,34)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 4.30n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...

US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair