Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'RNA-directed RNA polymerase' and Ligand = 'BDBM384096'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
RNA-directed RNA polymerase (Hepatitis C virus)	BDBM384096 (US10280167, Example 25) Show SMILES Nc1nc(nc2n(Cc3cccc(CN4CCCC4)c3)c(=O)[nH]c12)-c1ncc[nH]1 Show InChI InChI=1S/C20H22N8O/c21-16-15-19(26-18(25-16)17-22-6-7-23-17)28(20(29)24-15)12-14-5-3-4-13(10-14)11-27-8-1-2-9-27/h3-7,10H,1-2,8-9,11-12H2,(H,22,23)(H,24,29)(H2,21,25,26)	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	6	n/a	n/a	n/a	n/a
University of Nottingham					Assay Description Activation of human TLR7 results in robust production of interferon by plasmacytoid dendritic cells present in human blood. The potential of compound...				Br J Pharmacol 144: 317-22 (2005) BindingDB Entry DOI: 10.7270/Q2Z60RDV
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