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Found 1 hit Enz. Inhib. hit(s) with Target = 'RecQ-like DNA helicase BLM' and Ligand = 'BDBM50544268'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
RecQ-like DNA helicase BLM


(Homo sapiens (Human))		BDBM50544268
PNG
(CHEMBL4637736)
Show SMILES CCN(CC)CCNc1cc2nc3\C(CCn3c(=O)c2cc1F)=C\c1ccc(cc1O)C(C)C
Show InChI InChI=1S/C27H33FN4O2/c1-5-31(6-2)12-10-29-24-16-23-21(15-22(24)28)27(34)32-11-9-20(26(32)30-23)13-19-8-7-18(17(3)4)14-25(19)33/h7-8,13-17,29,33H,5-6,9-12H2,1-4H3/b20-13+
PDB
MMDB

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PC cid
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Article
PubMed
n/an/a 4.00E+3n/an/an/an/an/an/a



Sun Yat-sen University

Curated by ChEMBL


Assay Description
Inhibition of His-tagged BLM (642 to 1296 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) cells assessed as reduction in DNA unwi...

J Med Chem 63: 9752-9772 (2020)


Article DOI: 10.1021/acs.jmedchem.0c00917
BindingDB Entry DOI: 10.7270/Q2CN77GD
More data for this
Ligand-Target Pair