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Found 1 hit Enz. Inhib. hit(s) with Target = 'RecQ-like DNA helicase BLM' and Ligand = 'BDBM50544294'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
RecQ-like DNA helicase BLM


(Homo sapiens (Human))		BDBM50544294
PNG
(CHEMBL4641826)
Show SMILES CC(C)c1ccc(\C=C2/CCc3c2nc2ccccc2c3NCCCN(C)C)cc1
Show InChI InChI=1S/C27H33N3/c1-19(2)21-12-10-20(11-13-21)18-22-14-15-24-26(22)29-25-9-6-5-8-23(25)27(24)28-16-7-17-30(3)4/h5-6,8-13,18-19H,7,14-17H2,1-4H3,(H,28,29)/b22-18+
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MMDB

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PC cid
PC sid
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Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Sun Yat-sen University

Curated by ChEMBL


Assay Description
Inhibition of His-tagged BLM (642 to 1296 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) cells assessed as reduction in DNA unwi...

J Med Chem 63: 9752-9772 (2020)


Article DOI: 10.1021/acs.jmedchem.0c00917
BindingDB Entry DOI: 10.7270/Q2CN77GD
More data for this
Ligand-Target Pair