Compile Data Set for Download or QSAR

Found 6 hits Enz. Inhib. hit(s) with Target = 'Receptor-interacting serine/threonine-protein kinase 1' and Ligand = 'BDBM356296'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Receptor-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM356296 (US10604535, Example 173 | US9815850, Compound 173 ...) Show SMILES CN1c2ncccc2OC[C@H](NC(=O)c2nnc(o2)C2(CC2)c2ccccc2)C1=O |r| Show InChI InChI=1S/C21H19N5O4/c1-26-16-15(8-5-11-22-16)29-12-14(19(26)28)23-17(27)18-24-25-20(30-18)21(9-10-21)13-6-3-2-4-7-13/h2-8,11,14H,9-10,12H2,1H3,(H,23,27)/t14-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...				J Med Chem 48: 2906-15 (2005) BindingDB Entry DOI: 10.7270/Q2XW4N44
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM356296 (US10604535, Example 173 | US9815850, Compound 173 ...) Show SMILES CN1c2ncccc2OC[C@H](NC(=O)c2nnc(o2)C2(CC2)c2ccccc2)C1=O |r| Show InChI InChI=1S/C21H19N5O4/c1-26-16-15(8-5-11-22-16)29-12-14(19(26)28)23-17(27)18-24-25-20(30-18)21(9-10-21)13-6-3-2-4-7-13/h2-8,11,14H,9-10,12H2,1H3,(H,23,27)/t14-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...				J Med Chem 48: 2906-15 (2005) BindingDB Entry DOI: 10.7270/Q2XW4N44
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM356296 (US10604535, Example 173 | US9815850, Compound 173 ...) Show SMILES CN1c2ncccc2OC[C@H](NC(=O)c2nnc(o2)C2(CC2)c2ccccc2)C1=O |r| Show InChI InChI=1S/C21H19N5O4/c1-26-16-15(8-5-11-22-16)29-12-14(19(26)28)23-17(27)18-24-25-20(30-18)21(9-10-21)13-6-3-2-4-7-13/h2-8,11,14H,9-10,12H2,1H3,(H,23,27)/t14-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
Denali Therapeutics Inc. US Patent					Assay Description Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...				US Patent US9815850 (2017) BindingDB Entry DOI: 10.7270/Q2W0987J
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM356296 (US10604535, Example 173 | US9815850, Compound 173 ...) Show SMILES CN1c2ncccc2OC[C@H](NC(=O)c2nnc(o2)C2(CC2)c2ccccc2)C1=O |r| Show InChI InChI=1S/C21H19N5O4/c1-26-16-15(8-5-11-22-16)29-12-14(19(26)28)23-17(27)18-24-25-20(30-18)21(9-10-21)13-6-3-2-4-7-13/h2-8,11,14H,9-10,12H2,1H3,(H,23,27)/t14-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
Denali Therapeutics Inc. US Patent					Assay Description Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...				US Patent US9815850 (2017) BindingDB Entry DOI: 10.7270/Q2W0987J
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM356296 (US10604535, Example 173 | US9815850, Compound 173 ...) Show SMILES CN1c2ncccc2OC[C@H](NC(=O)c2nnc(o2)C2(CC2)c2ccccc2)C1=O |r| Show InChI InChI=1S/C21H19N5O4/c1-26-16-15(8-5-11-22-16)29-12-14(19(26)28)23-17(27)18-24-25-20(30-18)21(9-10-21)13-6-3-2-4-7-13/h2-8,11,14H,9-10,12H2,1H3,(H,23,27)/t14-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Denali Therapeutics Inc. US Patent					Assay Description Fluorescent polarization binding assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10...				US Patent US10604535 (2020) BindingDB Entry DOI: 10.7270/Q2VD72G8
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM356296 (US10604535, Example 173 | US9815850, Compound 173 ...) Show SMILES CN1c2ncccc2OC[C@H](NC(=O)c2nnc(o2)C2(CC2)c2ccccc2)C1=O |r| Show InChI InChI=1S/C21H19N5O4/c1-26-16-15(8-5-11-22-16)29-12-14(19(26)28)23-17(27)18-24-25-20(30-18)21(9-10-21)13-6-3-2-4-7-13/h2-8,11,14H,9-10,12H2,1H3,(H,23,27)/t14-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Denali Therapeutics Inc. US Patent					Assay Description Fluorescent polarization binding assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10...				US Patent US10604535 (2020) BindingDB Entry DOI: 10.7270/Q2VD72G8
					More data for this Ligand-Target Pair