Compile Data Set for Download or QSAR

Found 3 hits Enz. Inhib. hit(s) with Target = 'Receptor-interacting serine/threonine-protein kinase 1' and Ligand = 'BDBM356463'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Receptor-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM356463 (US10604535, Example 192 | US9815850, Compound 192 ...) Show SMILES C[C@H]1Oc2cccnc2N(C)C(=O)[C@H]1NC(=O)c1ncc(Cc2ccccc2)o1 |r| Show InChI InChI=1S/C21H20N4O4/c1-13-17(21(27)25(2)18-16(28-13)9-6-10-22-18)24-19(26)20-23-12-15(29-20)11-14-7-4-3-5-8-14/h3-10,12-13,17H,11H2,1-2H3,(H,24,26)/t13-,17+/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...				J Med Chem 48: 2906-15 (2005) BindingDB Entry DOI: 10.7270/Q2XW4N44
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM356463 (US10604535, Example 192 | US9815850, Compound 192 ...) Show SMILES C[C@H]1Oc2cccnc2N(C)C(=O)[C@H]1NC(=O)c1ncc(Cc2ccccc2)o1 |r| Show InChI InChI=1S/C21H20N4O4/c1-13-17(21(27)25(2)18-16(28-13)9-6-10-22-18)24-19(26)20-23-12-15(29-20)11-14-7-4-3-5-8-14/h3-10,12-13,17H,11H2,1-2H3,(H,24,26)/t13-,17+/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
Denali Therapeutics Inc. US Patent					Assay Description Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...				US Patent US9815850 (2017) BindingDB Entry DOI: 10.7270/Q2W0987J
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM356463 (US10604535, Example 192 | US9815850, Compound 192 ...) Show SMILES C[C@H]1Oc2cccnc2N(C)C(=O)[C@H]1NC(=O)c1ncc(Cc2ccccc2)o1 |r| Show InChI InChI=1S/C21H20N4O4/c1-13-17(21(27)25(2)18-16(28-13)9-6-10-22-18)24-19(26)20-23-12-15(29-20)11-14-7-4-3-5-8-14/h3-10,12-13,17H,11H2,1-2H3,(H,24,26)/t13-,17+/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Denali Therapeutics Inc. US Patent					Assay Description Fluorescent polarization binding assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10...				US Patent US10604535 (2020) BindingDB Entry DOI: 10.7270/Q2VD72G8
					More data for this Ligand-Target Pair