Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Receptor-type tyrosine-protein kinase FLT3' and Ligand = 'BDBM401017'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM401017 (US10004755, Compound UNC4291A) Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)N1CCN(C)CC1 |r,wD:15.15,(-7.14,-3.77,;-5.81,-3,;-4.47,-3.77,;-3.14,-3,;-1.81,-3.77,;-.47,-3,;-.47,-1.46,;.86,-.69,;2.2,-1.46,;3.66,-.99,;4.57,-2.23,;3.66,-3.48,;4.06,-4.96,;5.55,-5.36,;5.94,-6.85,;4.86,-7.94,;5.25,-9.43,;3.37,-7.54,;2.97,-6.05,;2.2,-3,;.86,-3.77,;4.06,.5,;5.55,.9,;5.94,2.39,;4.86,3.48,;3.37,3.08,;2.97,1.59,;5.25,4.96,;6.74,5.36,;7.14,6.85,;6.05,7.94,;6.45,9.43,;4.56,7.54,;4.17,6.05,)| Show InChI InChI=1S/C27H38N6O/c1-3-4-13-28-27-29-18-24-25(19-33(26(24)30-27)22-9-11-23(34)12-10-22)20-5-7-21(8-6-20)32-16-14-31(2)15-17-32/h5-8,18-19,22-23,34H,3-4,9-17H2,1-2H3,(H,28,29,30)/t22?,23-	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
NIH					Assay Description Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...				Bioorg Med Chem 17: 7884-93 (2009) BindingDB Entry DOI: 10.7270/Q26H4KR2
					More data for this Ligand-Target Pair