BindingDB PrimarySearch

Found 9 hits Enz. Inhib. hit(s) with Target = 'Receptor-type tyrosine-protein kinase FLT3' and Ligand = 'BDBM50177716'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50177716 (CHEMBL3813873 \| US11679110, Compound Pexidartinib ...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Competitive inhibition of FLT3 D835Y mutant (unknown origin) in presence of ATP				ACS Med Chem Lett 7: 476-81 (2016) Article DOI: 10.1021/acsmedchemlett.5b00498 BindingDB Entry DOI: 10.7270/Q2HD7XJD
Harvard Medical School Curated by ChEMBL					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50177716 (CHEMBL3813873 \| US11679110, Compound Pexidartinib ...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars		n/a	n/a	7.10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details BindingDB Entry DOI: 10.7270/Q2JW8K0M
TBA					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50177716 (CHEMBL3813873 \| US11679110, Compound Pexidartinib ...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	7.10	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL									J Med Chem 48: 680-93 (2005) Article DOI: 10.1016/j.bmcl.2022.128928 BindingDB Entry DOI: 10.7270/Q2FN1B5Z
Schering-Plough Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50177716 (CHEMBL3813873 \| US11679110, Compound Pexidartinib ...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	7.10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1016/j.bmcl.2022.128929 BindingDB Entry DOI: 10.7270/Q29W0KGP
TBA					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50177716 (CHEMBL3813873 \| US11679110, Compound Pexidartinib ...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01851 BindingDB Entry DOI: 10.7270/Q25Q515Z
TBA					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50177716 (CHEMBL3813873 \| US11679110, Compound Pexidartinib ...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Vichem Chemie Research Ltd Curated by ChEMBL					Assay Description Inhibition of recombinant FLT3 ITD mutant (unknown origin)				Eur J Med Chem 184: (2019) Article DOI: 10.1016/j.ejmech.2019.111710 BindingDB Entry DOI: 10.7270/Q27947ZV
Vichem Chemie Research Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50177716 (CHEMBL3813873 \| US11679110, Compound Pexidartinib ...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars		n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50177716 (CHEMBL3813873 \| US11679110, Compound Pexidartinib ...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
Vichem Chemie Research Ltd Curated by ChEMBL					Assay Description Inhibition of FL3 ITD mutant in human MV4-11 cells				Eur J Med Chem 184: (2019) Article DOI: 10.1016/j.ejmech.2019.111710 BindingDB Entry DOI: 10.7270/Q27947ZV
Vichem Chemie Research Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50177716 (CHEMBL3813873 \| US11679110, Compound Pexidartinib ...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	130	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Competitive inhibition of FLT3 ITD mutant (unknown origin) in presence of ATP				ACS Med Chem Lett 7: 476-81 (2016) Article DOI: 10.1021/acsmedchemlett.5b00498 BindingDB Entry DOI: 10.7270/Q2HD7XJD
Harvard Medical School Curated by ChEMBL					More data for this Ligand-Target Pair