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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Receptor-type tyrosine-protein kinase FLT3' and Ligand = 'BDBM50232774'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM50232774
PNG
(CHEMBL4061775)
Show SMILES Nc1ncc2ccc(Cl)cc2c1C#Cc1cccc(c1)C(=N)NO
Show InChI InChI=1S/C18H13ClN4O/c19-14-6-5-13-10-22-18(21)15(16(13)9-14)7-4-11-2-1-3-12(8-11)17(20)23-24/h1-3,5-6,8-10,24H,(H2,20,23)(H2,21,22)
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Article
PubMed
n/an/a 217n/an/an/an/an/an/a



Purdue University

Curated by ChEMBL


Assay Description
Inhibition of human FLT3 using EAIYAAPFAKKK as substrate preincubated for 20 mins followed by [gamma33P]ATP addition measured after 2 hrs by Hotspot ...

ACS Med Chem Lett 8: 492-497 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00468
BindingDB Entry DOI: 10.7270/Q2RV0QZ9
More data for this
Ligand-Target Pair