Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Receptor-type tyrosine-protein kinase FLT3' and Ligand = 'BDBM50513245'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50513245 (CHEMBL4457695) Show SMILES CN1CCN(CC1)c1ccc(Nc2cc(n[nH]2)-c2ccc(s2)C#N)cc1 Show InChI InChI=1S/C19H20N6S/c1-24-8-10-25(11-9-24)15-4-2-14(3-5-15)21-19-12-17(22-23-19)18-7-6-16(13-20)26-18/h2-7,12H,8-11H2,1H3,(H2,21,22,23)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of human FLT3 ITD mutant using EAIYAAPFAKKK peptide as substrate in presence of 33P-gamma ATP by hotspot kinase assay				Eur J Med Chem 176: 248-267 (2019) Article DOI: 10.1016/j.ejmech.2019.05.021 BindingDB Entry DOI: 10.7270/Q2FR00ZS
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