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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Receptor-type tyrosine-protein kinase FLT3 [D835Y]' and Ligand = 'BDBM397400'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Receptor-type tyrosine-protein kinase FLT3 [D835Y]


(Homo sapiens (Human))		BDBM397400
PNG
(US9987278, Compound Reference 10)
Show SMILES CCCNc1nc(NCCc2ccncc2)ncc1C(=O)Nc1cccc(NC(=O)CN(C)C(=O)C=C)c1
Show InChI InChI=1S/C27H32N8O3/c1-4-12-29-25-22(17-31-27(34-25)30-15-11-19-9-13-28-14-10-19)26(38)33-21-8-6-7-20(16-21)32-23(36)18-35(3)24(37)5-2/h5-10,13-14,16-17H,2,4,11-12,15,18H2,1,3H3,(H,32,36)(H,33,38)(H2,29,30,31,34)
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a<1n/an/an/an/an/an/a



BioCryst Pharmaceuticals



Assay Description
Quizartinib (Ambit Biosciences Corporation) was used as Reference Compound 1.6 μL (0.75 ng) of a mutant FLT3 protein (FLT3 D835Y, Life Technolog...

Bioorg Med Chem 17: 3934-58 (2009)


BindingDB Entry DOI: 10.7270/Q2J38VZJ
More data for this
Ligand-Target Pair