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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Receptor-type tyrosine-protein kinase FLT3 [D835Y]' and Ligand = 'BDBM397403'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Receptor-type tyrosine-protein kinase FLT3 [D835Y]


(Homo sapiens (Human))		BDBM397403
PNG
(US9987278, Compound Reference 13)
Show SMILES CCCNc1nc(NCCc2ccncc2)ncc1C(=O)Nc1cccc(NC(=O)CNC(=O)\C=C\CN2CCOCC2)c1
Show InChI InChI=1S/C31H39N9O4/c1-2-11-33-29-26(21-36-31(39-29)34-14-10-23-8-12-32-13-9-23)30(43)38-25-6-3-5-24(20-25)37-28(42)22-35-27(41)7-4-15-40-16-18-44-19-17-40/h3-9,12-13,20-21H,2,10-11,14-19,22H2,1H3,(H,35,41)(H,37,42)(H,38,43)(H2,33,34,36,39)/b7-4+
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 5.5n/an/an/an/an/an/a



BioCryst Pharmaceuticals



Assay Description
Quizartinib (Ambit Biosciences Corporation) was used as Reference Compound 1.6 μL (0.75 ng) of a mutant FLT3 protein (FLT3 D835Y, Life Technolog...

Bioorg Med Chem 17: 3934-58 (2009)


BindingDB Entry DOI: 10.7270/Q2J38VZJ
More data for this
Ligand-Target Pair