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Found 1 hit Enz. Inhib. hit(s) with Target = 'Rhodopsin kinase GRK1' and Ligand = 'BDBM50191325'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Rhodopsin kinase GRK1


(Bos taurus)		BDBM50191325
PNG
(CHEMBL3918278)
Show SMILES CC1=C(C(N=C(N1)c1ccc(cc1)C(F)(F)F)c1ccc(F)cc1)C(=O)Nc1ccc2[nH]ncc2c1 |c:4,t:1|
Show InChI InChI=1S/C26H19F4N5O/c1-14-22(25(36)33-20-10-11-21-17(12-20)13-31-35-21)23(15-4-8-19(27)9-5-15)34-24(32-14)16-2-6-18(7-3-16)26(28,29)30/h2-13,23H,1H3,(H,31,35)(H,32,34)(H,33,36)
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem

Similars
PubMed
n/an/a>1.00E+6n/an/an/an/an/an/a



Universit£ degli Studi di Messina

Curated by ChEMBL


Assay Description
Inhibition of bovine GRK1 (1 to 535 residues) assessed as decrease in phosphorylation of tubulin after 5 mins by SDS-PAGE analysis

J Med Chem 59: 9277-9294 (2016)


BindingDB Entry DOI: 10.7270/Q2348NB9
More data for this
Ligand-Target Pair