BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase A-Raf' and Ligand = 'BDBM50523706'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Serine/threonine-protein kinase A-Raf


(Homo sapiens (Human))		BDBM50523706
PNG
(CHEMBL4542639)
Show SMILES CNC(=O)c1cc(Oc2ccc(NC(=O)c3ccc(Cl)c(c3)C(F)(F)F)cc2)ccc1N
Show InChI InChI=1S/C22H17ClF3N3O3/c1-28-21(31)16-11-15(7-9-19(16)27)32-14-5-3-13(4-6-14)29-20(30)12-2-8-18(23)17(10-12)22(24,25)26/h2-11H,27H2,1H3,(H,28,31)(H,29,30)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 183n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of human ARAF using human His6-tagged MEK1 (K97R) as substrate preincubated for 20 mins followed by [33P-gamma]ATP addition and measured a...

Bioorg Med Chem Lett 29: 1605-1608 (2019)


Article DOI: 10.1016/j.bmcl.2019.04.047
BindingDB Entry DOI: 10.7270/Q29P352D
More data for this
Ligand-Target Pair