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Found 1 hit Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase A-Raf' and Ligand = 'BDBM50523707'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Serine/threonine-protein kinase A-Raf


(Homo sapiens (Human))		BDBM50523707
PNG
(CHEMBL4447617)
Show SMILES CNC(=O)c1cc(Oc2ccc(NC(=O)c3ccc(OC)cc3)cc2)ccc1N
Show InChI InChI=1S/C22H21N3O4/c1-24-22(27)19-13-18(11-12-20(19)23)29-17-9-5-15(6-10-17)25-21(26)14-3-7-16(28-2)8-4-14/h3-13H,23H2,1-2H3,(H,24,27)(H,25,26)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 211n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of human ARAF using human His6-tagged MEK1 (K97R) as substrate preincubated for 20 mins followed by [33P-gamma]ATP addition and measured a...

Bioorg Med Chem Lett 29: 1605-1608 (2019)


Article DOI: 10.1016/j.bmcl.2019.04.047
BindingDB Entry DOI: 10.7270/Q29P352D
More data for this
Ligand-Target Pair