BindingDB PrimarySearch

Found 5 hits Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase B-raf' and Ligand = 'BDBM50075581'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50075581 (CHEMBL3415555) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
UMR CNRS-Universit£ d'Orl£ans 7311 Curated by ChEMBL					Assay Description Inhibition of B-Raf V600E mutant (unknown origin) assessed as inhibition of phosphorylation of peptide substrate				J Med Chem 58: 1818-31 (2015) Article DOI: 10.1021/jm501667n BindingDB Entry DOI: 10.7270/Q27M09N7
UMR CNRS-Universit£ d'Orl£ans 7311 Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50075581 (CHEMBL3415555) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	<1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
UMR CNRS-Universit£ d'Orl£ans 7311 Curated by ChEMBL					Assay Description Inhibition of B-Raf V600E mutant in human A375 cells assessed as phosphorylation of ERK				J Med Chem 58: 1818-31 (2015) Article DOI: 10.1021/jm501667n BindingDB Entry DOI: 10.7270/Q27M09N7
UMR CNRS-Universit£ d'Orl£ans 7311 Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50075581 (CHEMBL3415555) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
UMR CNRS-Universit£ d'Orl£ans 7311 Curated by ChEMBL					Assay Description Activation of tumorigenic wild type B-Raf in human IPC-298 cells with Ras mutation assessed as phosphorylation of ERK				J Med Chem 58: 1818-31 (2015) Article DOI: 10.1021/jm501667n BindingDB Entry DOI: 10.7270/Q27M09N7
UMR CNRS-Universit£ d'Orl£ans 7311 Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50075581 (CHEMBL3415555) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a
UMR CNRS-Universit£ d'Orl£ans 7311 Curated by ChEMBL					Assay Description Binding affinity to B-Raf V600E mutant (unknown origin)				J Med Chem 58: 1818-31 (2015) Article DOI: 10.1021/jm501667n BindingDB Entry DOI: 10.7270/Q27M09N7
UMR CNRS-Universit£ d'Orl£ans 7311 Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50075581 (CHEMBL3415555) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a
UMR CNRS-Universit£ d'Orl£ans 7311 Curated by ChEMBL					Assay Description Binding affinity to wild type B-Raf (unknown origin)				J Med Chem 58: 1818-31 (2015) Article DOI: 10.1021/jm501667n BindingDB Entry DOI: 10.7270/Q27M09N7
UMR CNRS-Universit£ d'Orl£ans 7311 Curated by ChEMBL					More data for this Ligand-Target Pair