Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Serine/threonine-protein kinase B-raf (Homo sapiens (Human)) | BDBM50180338 (2-(3-Phenylpropylamino)-6-(3-acetamidophenyl)pyraz...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Cancer Research Curated by ChEMBL | Assay Description Growth inhibition in human melanoma cells WM266.4 expressing mutant B-RAF with SRB | J Med Chem 49: 407-16 (2006) Article DOI: 10.1021/jm050983g BindingDB Entry DOI: 10.7270/Q2KD1XH9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase B-raf (Homo sapiens (Human)) | BDBM50180338 (2-(3-Phenylpropylamino)-6-(3-acetamidophenyl)pyraz...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Cancer Research Curated by ChEMBL | Assay Description Inhibitory activity against human B-RAF | J Med Chem 49: 407-16 (2006) Article DOI: 10.1021/jm050983g BindingDB Entry DOI: 10.7270/Q2KD1XH9 | |||||||||||
More data for this Ligand-Target Pair |