Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Serine/threonine-protein kinase B-raf [V600E] (Homo sapiens (Human)) | BDBM25617 (N-[3-({5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl}carb...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 13 | n/a | n/a | n/a | n/a | 7.0 | 22 |
Plexxikon | Assay Description The in vitro kinase activities of wild type or mutants were determined by measuring phosphorylation of biotinylated-MEK protein using Perkin-Elmer s ... | Proc Natl Acad Sci U S A 105: 3041-6 (2008) Article DOI: 10.1073/pnas.0711741105 BindingDB Entry DOI: 10.7270/Q2SB441T | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |