Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase B-raf [V600E]' and Ligand = 'BDBM29728'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase B-raf [V600E] (Homo sapiens (Human))	BDBM29728 (Pyridoimidazolone, 27c) Show SMILES FC(F)(F)c1cccc(c1)C(=O)Nc1ccc(Oc2ccnc3[nH]c(=O)[nH]c23)cc1 Show InChI InChI=1S/C20H13F3N4O3/c21-20(22,23)12-3-1-2-11(10-12)18(28)25-13-4-6-14(7-5-13)30-15-8-9-24-17-16(15)26-19(29)27-17/h1-10H,(H,25,28)(H2,24,26,27,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.72E+4	n/a	n/a	n/a	n/a	7.2	22
The Institute of Cancer Research					Assay Description The biological activities (IC50s) of the compounds were determined against the B-RAF (V600E) mutant enzyme in vitro. GST-MEK1, B-RAF (V600E), and inh...				J Med Chem 52: 2255-64 (2009) Article DOI: 10.1021/jm801509w BindingDB Entry DOI: 10.7270/Q2PK0DGX
					More data for this Ligand-Target Pair