Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase B-raf [V600E]' and Ligand = 'BDBM29741'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase B-raf [V600E] (Homo sapiens (Human))	BDBM29741 (Pyridoimidazolone, 29e) Show SMILES Fc1ccc(cc1)S(=O)(=O)Nc1ccc(Oc2ccnc3[nH]c(=O)[nH]c23)cc1 Show InChI InChI=1S/C18H13FN4O4S/c19-11-1-7-14(8-2-11)28(25,26)23-12-3-5-13(6-4-12)27-15-9-10-20-17-16(15)21-18(24)22-17/h1-10,23H,(H2,20,21,22,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research					Assay Description The biological activities (IC50s) of the compounds were determined against the B-RAF (V600E) mutant enzyme in vitro. GST-MEK1, B-RAF (V600E), and inh...				J Med Chem 52: 2255-64 (2009) Article DOI: 10.1021/jm801509w BindingDB Entry DOI: 10.7270/Q2PK0DGX
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