BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase B-raf [V600E]' and Ligand = 'BDBM333744'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Serine/threonine-protein kinase B-raf [V600E]


(Homo sapiens (Human))		BDBM333744
PNG
(1-(5-(1,3- difluoro-2- methylpropan-2- yl)isoxazol...)
Show SMILES COc1cc2ncnc(Oc3cc(NC(=O)Nc4cc(on4)C(C)(CF)CF)ccc3F)c2cc1OC
Show InChI InChI=1S/C24H22F3N5O5/c1-24(10-25,11-26)20-9-21(32-37-20)31-23(33)30-13-4-5-15(27)17(6-13)36-22-14-7-18(34-2)19(35-3)8-16(14)28-12-29-22/h4-9,12H,10-11H2,1-3H3,(H2,30,31,32,33)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/a<250n/an/an/an/an/a



AMBIT BIOSCIENCES CORPORATION

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....

US Patent US9730937 (2017)


BindingDB Entry DOI: 10.7270/Q2M32XVC
More data for this
Ligand-Target Pair