Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase Chk1' and Ligand = 'BDBM14646'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human))	BDBM14646 ((3Z)-5-(4-hydroxy-3-methoxyphenyl)-3-(1H-indol-3-y...) Show SMILES COc1cc(ccc1O)-c1ccc2NC(=O)\C(=C/c3c[nH]c4ccccc34)c2c1 Show InChI InChI=1S/C24H18N2O3/c1-29-23-12-15(7-9-22(23)27)14-6-8-21-18(10-14)19(24(28)26-21)11-16-13-25-20-5-3-2-4-17(16)20/h2-13,25,27H,1H3,(H,26,28)/b19-11-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	7.4	22
Abbott Laboratories					Assay Description Chk1 kinase activity was assayed in reaction buffer containing substrate, enzyme, and inhibitor in the presence of 5uM ATP/[gamma-33P] ATP. 33P incor...				Bioorg Med Chem Lett 16: 421-6 (2006) Article DOI: 10.1016/j.bmcl.2005.09.064 BindingDB Entry DOI: 10.7270/Q22J694J
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