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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase Chk1' and Ligand = 'BDBM50325152'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))		BDBM50325152
PNG
(5-methyl-8-(4-(methylsulfinyl)phenyl)-[1,2,4]triaz...)
Show SMILES Cc1cc2n[nH]c(=O)n2c2cc(ccc12)-c1ccc(cc1)S(C)=O
Show InChI InChI=1S/C18H15N3O2S/c1-11-9-17-19-20-18(22)21(17)16-10-13(5-8-15(11)16)12-3-6-14(7-4-12)24(2)23/h3-10H,1-2H3,(H,20,22)
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MMDB

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n/an/a 90n/an/an/an/an/an/a



AstraZeneca R&D Boston

Curated by ChEMBL


Assay Description
Inhibition of His6-CHK1 expressed in baculovirus infected Sf9 cells

Bioorg Med Chem Lett 20: 5133-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.015
BindingDB Entry DOI: 10.7270/Q2FF3SJZ
More data for this
Ligand-Target Pair