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Found 1 hit Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase NLK' and Ligand = 'BDBM50537131'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Serine/threonine-protein kinase NLK


(Homo sapiens (Human))		BDBM50537131
PNG
(CHEMBL4575895)
Show SMILES COc1cc(Nc2ccnc3cc(ccc23)C#N)cc(OC)c1OC
Show InChI InChI=1S/C19H17N3O3/c1-23-17-9-13(10-18(24-2)19(17)25-3)22-15-6-7-21-16-8-12(11-20)4-5-14(15)16/h4-10H,1-3H3,(H,21,22)
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

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GoogleScholar
AffyNet 
PC cid
PC sid
PDB
UniChem
Article
PubMed
n/an/an/a 28n/an/an/an/an/a



Johann Wolfgang Goethe University

Curated by ChEMBL


Assay Description
Binding affinity to biotinylated full length human NLK expressed in Escherichia coli incubated for 1.5 hrs by fluorescent tracer dependent TR-FRET ba...

J Med Chem 62: 2830-2836 (2019)


Article DOI: 10.1021/acs.jmedchem.8b01213
BindingDB Entry DOI: 10.7270/Q28919C7
More data for this
Ligand-Target Pair