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Found 1 hit Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase Nek2' and Ligand = 'BDBM50235006'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Serine/threonine-protein kinase Nek2


(Homo sapiens (Human))		BDBM50235006
PNG
(CHEMBL4064022)
Show SMILES CC(Oc1cc(ccc1C(N)=O)-c1cnc2cc(ccn12)N1CCN(C)CC1)c1ccccc1C(F)(F)F
Show InChI InChI=1S/C28H28F3N5O2/c1-18(21-5-3-4-6-23(21)28(29,30)31)38-25-15-19(7-8-22(25)27(32)37)24-17-33-26-16-20(9-10-36(24)26)35-13-11-34(2)12-14-35/h3-10,15-18H,11-14H2,1-2H3,(H2,32,37)
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PC sid
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Similars
Article
PubMed
n/an/a 2.17E+3n/an/an/an/an/an/a



East China Normal University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His6-tagged full-length recombinant human NEK2 expressed in baculovirus infected sf21 cells using biotin labelled-STK-3 subs...

Eur J Med Chem 126: 1083-1106 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.026
BindingDB Entry DOI: 10.7270/Q2GT5QFN
More data for this
Ligand-Target Pair