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Found 1 hit Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase WNK1' and Ligand = 'BDBM50258567'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Serine/threonine-protein kinase WNK1


(Homo sapiens (Human))		BDBM50258567
PNG
(CHEMBL4060478)
Show SMILES CNc1nc(cs1)-c1cc(ccn1)C(=O)N1CCN(Cc2ccc(Cl)cc2)CC1
Show InChI InChI=1S/C21H22ClN5OS/c1-23-21-25-19(14-29-21)18-12-16(6-7-24-18)20(28)27-10-8-26(9-11-27)13-15-2-4-17(22)5-3-15/h2-7,12,14H,8-11,13H2,1H3,(H,23,25)
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Novartis Institutes for BioMedical Research, Inc. , Cambridge, Massachusetts 02139-4133, United States.

Curated by ChEMBL


Assay Description
Allosteric inhibition of WNK1 (unknown origin) expressed in HEK293 cells co-expressing flag-OSR1 assessed as reduction in sorbitol-stimulated OSR1 ph...

J Med Chem 60: 7099-7107 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00708
BindingDB Entry DOI: 10.7270/Q29W0HXP
More data for this
Ligand-Target Pair