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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase pim-1/pim-2/pim-3' and Ligand = 'BDBM238534'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Serine/threonine-protein kinase pim-1/pim-2/pim-3


(Homo sapiens (Human))		BDBM238534
PNG
(US9394297, 174)
Show SMILES Cc1nc2cccc(-c3cc4C(=O)NCCn4c3)c2nc1NC(C)(C)C
Show InChI InChI=1S/C20H23N5O/c1-12-18(24-20(2,3)4)23-17-14(6-5-7-15(17)22-12)13-10-16-19(26)21-8-9-25(16)11-13/h5-7,10-11H,8-9H2,1-4H3,(H,21,26)(H,23,24)
PDB

UniProtKB/SwissProt

antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 4.56E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of pan Pim in human KMS-12-BM cells assessed as reduction in phosphorylation of biotinylated-BAD peptide at Serine 112 residue after 110 m...

J Med Chem 59: 6407-30 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00610
BindingDB Entry DOI: 10.7270/Q2125X4G
More data for this
Ligand-Target Pair