Compile Data Set for Download or QSAR

Found 5 hits Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase pim-1' and Ligand = 'BDBM35052'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM35052 (K00152 | US10047093, 8-39 | US10392392, Example 8-...) Show SMILES Clc1cccc(c1)-c1cnc2ccc(NC3CCOCC3)nn12 Show InChI InChI=1S/C17H17ClN4O/c18-13-3-1-2-12(10-13)15-11-19-17-5-4-16(21-22(15)17)20-14-6-8-23-9-7-14/h1-5,10-11,14H,6-9H2,(H,20,21)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	US Patent	n/a	n/a	48	n/a	n/a	n/a	n/a	n/a	25
TOLERO PHARMACEUTICALS, INC. US Patent					Assay Description One illustrative manner in which Pim-1 kinase activity can be determined is by quantifying the amount of ATP remaining in solution after an in vitro ...				US Patent US10047093 (2018) BindingDB Entry DOI: 10.7270/Q298890X
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM35052 (K00152 | US10047093, 8-39 | US10392392, Example 8-...) Show SMILES Clc1cccc(c1)-c1cnc2ccc(NC3CCOCC3)nn12 Show InChI InChI=1S/C17H17ClN4O/c18-13-3-1-2-12(10-13)15-11-19-17-5-4-16(21-22(15)17)20-14-6-8-23-9-7-14/h1-5,10-11,14H,6-9H2,(H,20,21)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	US Patent	n/a	n/a	48	n/a	n/a	n/a	n/a	n/a	25
Tolero Pharmaceuticals, Inc. US Patent					Assay Description These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...				US Patent US9416132 (2016) BindingDB Entry DOI: 10.7270/Q2CV4GNG
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM35052 (K00152 | US10047093, 8-39 | US10392392, Example 8-...) Show SMILES Clc1cccc(c1)-c1cnc2ccc(NC3CCOCC3)nn12 Show InChI InChI=1S/C17H17ClN4O/c18-13-3-1-2-12(10-13)15-11-19-17-5-4-16(21-22(15)17)20-14-6-8-23-9-7-14/h1-5,10-11,14H,6-9H2,(H,20,21)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	US Patent	n/a	n/a	48	n/a	n/a	n/a	n/a	n/a	n/a
SUMITOMO DAINIPPON PHARMA ONCOLOGY, INC. US Patent					Assay Description One illustrative manner in which Pim-1 kinase activity can be determined is by quantifying the amount of ATP remaining in solution after an in vitro ...				US Patent US10875864 (2020) BindingDB Entry DOI: 10.7270/Q21G0QBX
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM35052 (K00152 | US10047093, 8-39 | US10392392, Example 8-...) Show SMILES Clc1cccc(c1)-c1cnc2ccc(NC3CCOCC3)nn12 Show InChI InChI=1S/C17H17ClN4O/c18-13-3-1-2-12(10-13)15-11-19-17-5-4-16(21-22(15)17)20-14-6-8-23-9-7-14/h1-5,10-11,14H,6-9H2,(H,20,21)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	US Patent	n/a	n/a	48	n/a	n/a	n/a	n/a	n/a	n/a
Tolero Pharmaceuticals, Inc. US Patent					Assay Description One illustrative manner in which Pim-1 kinase activity can be determined is by quantifying the amount of ATP remaining in solution after an in vitro ...				US Patent US10392392 (2019) BindingDB Entry DOI: 10.7270/Q27P91RC
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM35052 (K00152 | US10047093, 8-39 | US10392392, Example 8-...) Show SMILES Clc1cccc(c1)-c1cnc2ccc(NC3CCOCC3)nn12 Show InChI InChI=1S/C17H17ClN4O/c18-13-3-1-2-12(10-13)15-11-19-17-5-4-16(21-22(15)17)20-14-6-8-23-9-7-14/h1-5,10-11,14H,6-9H2,(H,20,21)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	7.5	25
University Hospital Basel					Assay Description Phosphorylation reactions were monitored using a coupled-enzyme assay in which ADP production was coupled to NADH oxidation by pyruvate kinase and la...				Cancer Res 67: 6916-24 (2007) Article DOI: 10.1158/0008-5472.CAN-07-0320 BindingDB Entry DOI: 10.7270/Q23X850Z
					More data for this Ligand-Target Pair