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Found 1 hit Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase pim-1' and Ligand = 'BDBM50261865'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM50261865
PNG
(CHEMBL4073332)
Show SMILES NC(=O)c1cc(Cl)c2c(Cl)c(C3CCCO3)n(C3CCCNC3)c2n1
Show InChI InChI=1S/C17H20Cl2N4O2/c18-10-7-11(16(20)24)22-17-13(10)14(19)15(12-4-2-6-25-12)23(17)9-3-1-5-21-8-9/h7,9,12,21H,1-6,8H2,(H2,20,24)
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PC cid
PC sid
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Similars
Article
PubMed
n/an/a 31n/an/an/an/an/an/a



IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com.

Curated by ChEMBL


Assay Description
Inhibition of PIM1 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues by TR-FRET assay

Bioorg Med Chem Lett 27: 4735-4740 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.068
BindingDB Entry DOI: 10.7270/Q2NG4T34
More data for this
Ligand-Target Pair