Found 4 hits Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase pim-2' and Ligand = 'BDBM377252' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM377252
(N-{4-[(3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperid...)Show SMILES COc1ccc(F)c(c1F)-c1nc(ccc1F)C(=O)Nc1cnc2OCCc2c1N1C[C@H](C)[C@@H](O)[C@H](N)C1 |r,wU:35.39,31.35,wD:33.37,(7.19,4.24,;5.85,5.01,;4.52,4.24,;3.19,5,;1.85,4.24,;1.85,2.7,;.52,1.93,;3.19,1.92,;4.52,2.7,;5.85,1.93,;3.19,.38,;1.85,-.39,;1.85,-1.93,;3.19,-2.7,;4.52,-1.93,;4.52,-.39,;5.85,.38,;.52,-2.7,;.52,-4.24,;-.82,-1.93,;-2.15,-2.7,;-2.15,-4.24,;-3.48,-5.01,;-4.82,-4.24,;-6.28,-4.71,;-7.19,-3.47,;-6.28,-2.22,;-4.82,-2.7,;-3.48,-1.93,;-3.48,-.39,;-2.15,.38,;-2.15,1.92,;-.82,2.69,;-3.48,2.69,;-3.48,4.23,;-4.82,1.92,;-6.15,2.69,;-4.82,.38,)| Show InChI InChI=1S/C26H26F3N5O4/c1-12-10-34(11-16(30)24(12)35)23-13-7-8-38-26(13)31-9-18(23)33-25(36)17-5-3-15(28)22(32-17)20-14(27)4-6-19(37-2)21(20)29/h3-6,9,12,16,24,35H,7-8,10-11,30H2,1-2H3,(H,33,36)/t12-,16+,24+/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
Curacyte Chemistry GmbH
| Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b... |
J Med Chem 49: 4116-26 (2006)
BindingDB Entry DOI: 10.7270/Q2FJ2K39 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM377252
(N-{4-[(3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperid...)Show SMILES COc1ccc(F)c(c1F)-c1nc(ccc1F)C(=O)Nc1cnc2OCCc2c1N1C[C@H](C)[C@@H](O)[C@H](N)C1 |r,wU:35.39,31.35,wD:33.37,(7.19,4.24,;5.85,5.01,;4.52,4.24,;3.19,5,;1.85,4.24,;1.85,2.7,;.52,1.93,;3.19,1.92,;4.52,2.7,;5.85,1.93,;3.19,.38,;1.85,-.39,;1.85,-1.93,;3.19,-2.7,;4.52,-1.93,;4.52,-.39,;5.85,.38,;.52,-2.7,;.52,-4.24,;-.82,-1.93,;-2.15,-2.7,;-2.15,-4.24,;-3.48,-5.01,;-4.82,-4.24,;-6.28,-4.71,;-7.19,-3.47,;-6.28,-2.22,;-4.82,-2.7,;-3.48,-1.93,;-3.48,-.39,;-2.15,.38,;-2.15,1.92,;-.82,2.69,;-3.48,2.69,;-3.48,4.23,;-4.82,1.92,;-6.15,2.69,;-4.82,.38,)| Show InChI InChI=1S/C26H26F3N5O4/c1-12-10-34(11-16(30)24(12)35)23-13-7-8-38-26(13)31-9-18(23)33-25(36)17-5-3-15(28)22(32-17)20-14(27)4-6-19(37-2)21(20)29/h3-6,9,12,16,24,35H,7-8,10-11,30H2,1-2H3,(H,33,36)/t12-,16+,24+/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Pim-2 kinase assay-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay buffer (50 m... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2GB2776 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM377252
(N-{4-[(3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperid...)Show SMILES COc1ccc(F)c(c1F)-c1nc(ccc1F)C(=O)Nc1cnc2OCCc2c1N1C[C@H](C)[C@@H](O)[C@H](N)C1 |r,wU:35.39,31.35,wD:33.37,(7.19,4.24,;5.85,5.01,;4.52,4.24,;3.19,5,;1.85,4.24,;1.85,2.7,;.52,1.93,;3.19,1.92,;4.52,2.7,;5.85,1.93,;3.19,.38,;1.85,-.39,;1.85,-1.93,;3.19,-2.7,;4.52,-1.93,;4.52,-.39,;5.85,.38,;.52,-2.7,;.52,-4.24,;-.82,-1.93,;-2.15,-2.7,;-2.15,-4.24,;-3.48,-5.01,;-4.82,-4.24,;-6.28,-4.71,;-7.19,-3.47,;-6.28,-2.22,;-4.82,-2.7,;-3.48,-1.93,;-3.48,-.39,;-2.15,.38,;-2.15,1.92,;-.82,2.69,;-3.48,2.69,;-3.48,4.23,;-4.82,1.92,;-6.15,2.69,;-4.82,.38,)| Show InChI InChI=1S/C26H26F3N5O4/c1-12-10-34(11-16(30)24(12)35)23-13-7-8-38-26(13)31-9-18(23)33-25(36)17-5-3-15(28)22(32-17)20-14(27)4-6-19(37-2)21(20)29/h3-6,9,12,16,24,35H,7-8,10-11,30H2,1-2H3,(H,33,36)/t12-,16+,24+/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation; Incyte Holdings Corporation
US Patent
| Assay Description
Pim-1 and Pim-3 kinase assays—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μcompound/DMSO in the assa... |
US Patent US10828290 (2020)
BindingDB Entry DOI: 10.7270/Q2TB19Z5 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM377252
(N-{4-[(3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperid...)Show SMILES COc1ccc(F)c(c1F)-c1nc(ccc1F)C(=O)Nc1cnc2OCCc2c1N1C[C@H](C)[C@@H](O)[C@H](N)C1 |r,wU:35.39,31.35,wD:33.37,(7.19,4.24,;5.85,5.01,;4.52,4.24,;3.19,5,;1.85,4.24,;1.85,2.7,;.52,1.93,;3.19,1.92,;4.52,2.7,;5.85,1.93,;3.19,.38,;1.85,-.39,;1.85,-1.93,;3.19,-2.7,;4.52,-1.93,;4.52,-.39,;5.85,.38,;.52,-2.7,;.52,-4.24,;-.82,-1.93,;-2.15,-2.7,;-2.15,-4.24,;-3.48,-5.01,;-4.82,-4.24,;-6.28,-4.71,;-7.19,-3.47,;-6.28,-2.22,;-4.82,-2.7,;-3.48,-1.93,;-3.48,-.39,;-2.15,.38,;-2.15,1.92,;-.82,2.69,;-3.48,2.69,;-3.48,4.23,;-4.82,1.92,;-6.15,2.69,;-4.82,.38,)| Show InChI InChI=1S/C26H26F3N5O4/c1-12-10-34(11-16(30)24(12)35)23-13-7-8-38-26(13)31-9-18(23)33-25(36)17-5-3-15(28)22(32-17)20-14(27)4-6-19(37-2)21(20)29/h3-6,9,12,16,24,35H,7-8,10-11,30H2,1-2H3,(H,33,36)/t12-,16+,24+/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Holdings Corporation; Incyte Corporation
US Patent
| Assay Description
Pim-2 kinase assay-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay buffer (50 m... |
US Patent US10517858 (2019)
BindingDB Entry DOI: 10.7270/Q2XD1422 |
More data for this
Ligand-Target Pair | |
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