Found 10 hits Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase pim-2' and Ligand = 'BDBM50364776' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM50364776
(CHEMBL1952141 | CHEMBL1952329)Show SMILES CN1CCC(CNc2ccc3ncc(-c4cccc(OC(F)(F)F)c4)n3n2)CC1 Show InChI InChI=1S/C20H22F3N5O/c1-27-9-7-14(8-10-27)12-24-18-5-6-19-25-13-17(28(19)26-18)15-3-2-4-16(11-15)29-20(21,22)23/h2-6,11,13-14H,7-10,12H2,1H3,(H,24,26) | PDB MMDB
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| Article PubMed
| 610 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description Inhibition of PIM2 kinase (unknown origin) using Biotin-AGAGRSRHSSYPAGT-OH as substrate after 2 hrs by alphascreen assay |
J Med Chem 58: 8373-86 (2015)
Article DOI: 10.1021/acs.jmedchem.5b01275 BindingDB Entry DOI: 10.7270/Q2H41VGN |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM50364776
(CHEMBL1952141 | CHEMBL1952329)Show SMILES CN1CCC(CNc2ccc3ncc(-c4cccc(OC(F)(F)F)c4)n3n2)CC1 Show InChI InChI=1S/C20H22F3N5O/c1-27-9-7-14(8-10-27)12-24-18-5-6-19-25-13-17(28(19)26-18)15-3-2-4-16(11-15)29-20(21,22)23/h2-6,11,13-14H,7-10,12H2,1H3,(H,24,26) | PDB MMDB
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| Article PubMed
| 610 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description Inhibition of PIM2 (unknown origin) |
ACS Med Chem Lett 4: 1193-7 (2013)
Article DOI: 10.1021/ml400307j BindingDB Entry DOI: 10.7270/Q23X8840 |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM50364776
(CHEMBL1952141 | CHEMBL1952329)Show SMILES CN1CCC(CNc2ccc3ncc(-c4cccc(OC(F)(F)F)c4)n3n2)CC1 Show InChI InChI=1S/C20H22F3N5O/c1-27-9-7-14(8-10-27)12-24-18-5-6-19-25-13-17(28(19)26-18)15-3-2-4-16(11-15)29-20(21,22)23/h2-6,11,13-14H,7-10,12H2,1H3,(H,24,26) | PDB MMDB
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| n/a | n/a | 362 | n/a | n/a | n/a | n/a | n/a | n/a |
Spanish National Cancer Research Centre (CNIO)
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PIM2 using KKRNRTLTV as substrate in presence of [gamma-33P]ATP incubated for 40 mins by scintillation counting |
Eur J Med Chem 168: 87-109 (2019)
Article DOI: 10.1016/j.ejmech.2019.02.022 BindingDB Entry DOI: 10.7270/Q2XW4P4J |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM50364776
(CHEMBL1952141 | CHEMBL1952329)Show SMILES CN1CCC(CNc2ccc3ncc(-c4cccc(OC(F)(F)F)c4)n3n2)CC1 Show InChI InChI=1S/C20H22F3N5O/c1-27-9-7-14(8-10-27)12-24-18-5-6-19-25-13-17(28(19)26-18)15-3-2-4-16(11-15)29-20(21,22)23/h2-6,11,13-14H,7-10,12H2,1H3,(H,24,26) | PDB MMDB
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| n/a | n/a | 363 | n/a | n/a | n/a | n/a | n/a | n/a |
Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital
Curated by ChEMBL
| Assay Description Inhibition of human Pim-2 expressed in Escherichia coli cells using KKRNRTLTV as substrate after 40 mins by [gamma-33P]-ATP assay |
Eur J Med Chem 178: 468-483 (2019)
Article DOI: 10.1016/j.ejmech.2019.06.002 BindingDB Entry DOI: 10.7270/Q22Z18W7 |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM50364776
(CHEMBL1952141 | CHEMBL1952329)Show SMILES CN1CCC(CNc2ccc3ncc(-c4cccc(OC(F)(F)F)c4)n3n2)CC1 Show InChI InChI=1S/C20H22F3N5O/c1-27-9-7-14(8-10-27)12-24-18-5-6-19-25-13-17(28(19)26-18)15-3-2-4-16(11-15)29-20(21,22)23/h2-6,11,13-14H,7-10,12H2,1H3,(H,24,26) | PDB MMDB
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| Article PubMed
| n/a | n/a | 363 | n/a | n/a | n/a | n/a | n/a | n/a |
Keimyung University
Curated by ChEMBL
| Assay Description Inhibition of PIM2 (unknown origin) |
Bioorg Med Chem Lett 28: 2513-2517 (2018)
Article DOI: 10.1016/j.bmcl.2018.05.054 BindingDB Entry DOI: 10.7270/Q2HX1G50 |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM50364776
(CHEMBL1952141 | CHEMBL1952329)Show SMILES CN1CCC(CNc2ccc3ncc(-c4cccc(OC(F)(F)F)c4)n3n2)CC1 Show InChI InChI=1S/C20H22F3N5O/c1-27-9-7-14(8-10-27)12-24-18-5-6-19-25-13-17(28(19)26-18)15-3-2-4-16(11-15)29-20(21,22)23/h2-6,11,13-14H,7-10,12H2,1H3,(H,24,26) | PDB MMDB
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| | n/a | n/a | 363 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM50364776
(CHEMBL1952141 | CHEMBL1952329)Show SMILES CN1CCC(CNc2ccc3ncc(-c4cccc(OC(F)(F)F)c4)n3n2)CC1 Show InChI InChI=1S/C20H22F3N5O/c1-27-9-7-14(8-10-27)12-24-18-5-6-19-25-13-17(28(19)26-18)15-3-2-4-16(11-15)29-20(21,22)23/h2-6,11,13-14H,7-10,12H2,1H3,(H,24,26) | PDB MMDB
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| Article PubMed
| n/a | n/a | 363 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description Inhibition of PIM2 (unknown origin) |
Eur J Med Chem 163: 413-427 (2019)
Article DOI: 10.1016/j.ejmech.2018.11.072 BindingDB Entry DOI: 10.7270/Q2736V7K |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM50364776
(CHEMBL1952141 | CHEMBL1952329)Show SMILES CN1CCC(CNc2ccc3ncc(-c4cccc(OC(F)(F)F)c4)n3n2)CC1 Show InChI InChI=1S/C20H22F3N5O/c1-27-9-7-14(8-10-27)12-24-18-5-6-19-25-13-17(28(19)26-18)15-3-2-4-16(11-15)29-20(21,22)23/h2-6,11,13-14H,7-10,12H2,1H3,(H,24,26) | PDB MMDB
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| n/a | n/a | 363 | n/a | n/a | n/a | n/a | n/a | n/a |
Cylene Pharmaceuticals
Curated by ChEMBL
| Assay Description Competitive inhibition of PIM2 in presence of ATP |
J Med Chem 55: 8199-208 (2012)
Article DOI: 10.1021/jm3009234 BindingDB Entry DOI: 10.7270/Q2930V9T |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM50364776
(CHEMBL1952141 | CHEMBL1952329)Show SMILES CN1CCC(CNc2ccc3ncc(-c4cccc(OC(F)(F)F)c4)n3n2)CC1 Show InChI InChI=1S/C20H22F3N5O/c1-27-9-7-14(8-10-27)12-24-18-5-6-19-25-13-17(28(19)26-18)15-3-2-4-16(11-15)29-20(21,22)23/h2-6,11,13-14H,7-10,12H2,1H3,(H,24,26) | PDB MMDB
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| Article PubMed
| n/a | n/a | 363 | n/a | n/a | n/a | n/a | n/a | n/a |
Spanish National Cancer Research Centre (CNIO)
Curated by ChEMBL
| Assay Description Inhibition of PIM2 |
Bioorg Med Chem Lett 22: 1591-7 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.130 BindingDB Entry DOI: 10.7270/Q21R6QZ1 |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM50364776
(CHEMBL1952141 | CHEMBL1952329)Show SMILES CN1CCC(CNc2ccc3ncc(-c4cccc(OC(F)(F)F)c4)n3n2)CC1 Show InChI InChI=1S/C20H22F3N5O/c1-27-9-7-14(8-10-27)12-24-18-5-6-19-25-13-17(28(19)26-18)15-3-2-4-16(11-15)29-20(21,22)23/h2-6,11,13-14H,7-10,12H2,1H3,(H,24,26) | PDB MMDB
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| Article PubMed
| n/a | n/a | 618 | n/a | n/a | n/a | n/a | n/a | n/a |
Spanish National Cancer Research Centre (CNIO)
Curated by ChEMBL
| Assay Description Inhibition of His tagged human recombinant PIM2 using PIM tide (ARKRRRHPSGPPTA) as substrate incubated for 1 hr by fluorescence based assay |
Eur J Med Chem 168: 87-109 (2019)
Article DOI: 10.1016/j.ejmech.2019.02.022 BindingDB Entry DOI: 10.7270/Q2XW4P4J |
More data for this Ligand-Target Pair | |