Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase pim-3' and Ligand = 'BDBM151872'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase pim-3 (Homo sapiens (Human))	BDBM151872 (US8987457, 66) Show SMILES C[C@H]1CN(C[C@@H](N)[C@H]1n1cc(CO)nn1)c1ccncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cccc1F |r,wU:5.5,1.0,7.8,(-.67,.56,;-2,-.21,;-2,-1.75,;-3.33,-2.52,;-4.67,-1.75,;-4.67,-.21,;-6,.56,;-3.33,.56,;-3.33,2.1,;-2.09,3.01,;-2.56,4.47,;-1.79,5.8,;-2.56,7.14,;-4.1,4.47,;-4.58,3.01,;-3.33,-4.06,;-4.67,-4.83,;-4.67,-6.37,;-3.33,-7.14,;-2,-6.37,;-2,-4.83,;-.67,-4.06,;.67,-4.83,;.67,-6.37,;2,-4.06,;3.33,-4.83,;4.67,-4.06,;4.67,-2.52,;6,-1.75,;3.33,-1.75,;2,-2.52,;3.33,-.21,;2,.56,;.67,-.21,;2,2.1,;3.33,2.87,;4.67,2.1,;4.67,.56,;6,-.21,)| Show InChI InChI=1S/C26H25F3N8O2/c1-14-10-36(12-19(30)25(14)37-11-15(13-38)34-35-37)22-7-8-31-9-21(22)33-26(39)20-6-5-18(29)24(32-20)23-16(27)3-2-4-17(23)28/h2-9,11,14,19,25,38H,10,12-13,30H2,1H3,(H,33,39)/t14-,19+,25-/m0/s1	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.730	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description Pim 1, Pim 2 & Pim 3 AlphaScreen assays using high ATP (11-125.times. ATP Km) were used to determine the biochemical activity of the inhibitors. The ...				US Patent US8987457 (2015) BindingDB Entry DOI: 10.7270/Q2765D2M
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