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Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase pim-3' and Ligand = 'BDBM291198'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM291198
PNG
(N-{4-[(3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperid...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NC(=O)c1ccc2ccc(cc2n1)N1CCN(C)CC1 |r|
Show InChI InChI=1S/C26H33N7O2/c1-17-15-33(16-20(27)25(17)34)24-7-8-28-14-23(24)30-26(35)21-6-4-18-3-5-19(13-22(18)29-21)32-11-9-31(2)10-12-32/h3-8,13-14,17,20,25,34H,9-12,15-16,27H2,1-2H3,(H,30,35)/t17-,20+,25+/m0/s1
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Bryn Mawr College



Assay Description
Pim-1 and Pim-3 kinase assays-20 uL reactions were run in white 384 well polystyrene plates dotted with 0.8 uL compound/DMSO in the assay buffer (50 ...


J Med Chem 51: 4968-77 (2008)


BindingDB Entry DOI: 10.7270/Q2ZC856W
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM291198
PNG
(N-{4-[(3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperid...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NC(=O)c1ccc2ccc(cc2n1)N1CCN(C)CC1 |r|
Show InChI InChI=1S/C26H33N7O2/c1-17-15-33(16-20(27)25(17)34)24-7-8-28-14-23(24)30-26(35)21-6-4-18-3-5-19(13-22(18)29-21)32-11-9-31(2)10-12-32/h3-8,13-14,17,20,25,34H,9-12,15-16,27H2,1-2H3,(H,30,35)/t17-,20+,25+/m0/s1
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/a7.525



Incyte Corporation

US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)


BindingDB Entry DOI: 10.7270/Q2X92DB9
More data for this
Ligand-Target Pair