Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Short transient receptor potential channel 6' and Ligand = 'BDBM466596'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Short transient receptor potential channel 6 (Homo sapiens (Human))	BDBM466596 (US10800757, Compound 12 | US10889568, Compound 12 ...) Show SMILES COc1ccc(Oc2cnc(cc2OC)C(=O)N2CCN(CC2)c2ccc(N)nc2)cc1 Show InChI InChI=1S/C23H25N5O4/c1-30-17-4-6-18(7-5-17)32-21-15-25-19(13-20(21)31-2)23(29)28-11-9-27(10-12-28)16-3-8-22(24)26-14-16/h3-8,13-15H,9-12H2,1-2H3,(H2,24,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC US Patent					Assay Description This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...				US Patent US10800757 (2020) BindingDB Entry DOI: 10.7270/Q2PV6PDC
					More data for this Ligand-Target Pair
Short transient receptor potential channel 6 (Homo sapiens (Human))	BDBM466596 (US10800757, Compound 12 | US10889568, Compound 12 ...) Show SMILES COc1ccc(Oc2cnc(cc2OC)C(=O)N2CCN(CC2)c2ccc(N)nc2)cc1 Show InChI InChI=1S/C23H25N5O4/c1-30-17-4-6-18(7-5-17)32-21-15-25-19(13-20(21)31-2)23(29)28-11-9-27(10-12-28)16-3-8-22(24)26-14-16/h3-8,13-15H,9-12H2,1-2H3,(H2,24,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...				US Patent US10889568 (2021) BindingDB Entry DOI: 10.7270/Q2H99894
					More data for this Ligand-Target Pair