Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sialidase-4 (Homo sapiens (Human)) | BDBM50330326 ((4S,5R,6R)-5-Acetylamino-4-guanidino-6-((1R,3R)-1,...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 2.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Alberta Curated by ChEMBL | Assay Description Inhibition of human N-terminal MBP-fused NEU4 expressed in Escherichia coli using 4MU-NANA as substrate preincubated for 15 mins followed by substrat... | J Med Chem 61: 1990-2008 (2018) Article DOI: 10.1021/acs.jmedchem.7b01574 BindingDB Entry DOI: 10.7270/Q2XS5XV6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sialidase-4 (Homo sapiens (Human)) | BDBM50330326 ((4S,5R,6R)-5-Acetylamino-4-guanidino-6-((1R,3R)-1,...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 2.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Alberta Curated by ChEMBL | Assay Description Inhibition of MBP-fused recombinant human neuraminidase 4 expressed in Escherichia coli using 4MU-NANA as substrate preincubated for 15 mins followed... | Bioorg Med Chem 26: 5349-5358 (2018) Article DOI: 10.1016/j.bmc.2018.05.035 BindingDB Entry DOI: 10.7270/Q29W0J57 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sialidase-4 (Homo sapiens (Human)) | BDBM50330326 ((4S,5R,6R)-5-Acetylamino-4-guanidino-6-((1R,3R)-1,...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 4.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01612 BindingDB Entry DOI: 10.7270/Q21J9FT0 | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sialidase-4 (Homo sapiens (Human)) | BDBM50330326 ((4S,5R,6R)-5-Acetylamino-4-guanidino-6-((1R,3R)-1,...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 4.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Alberta Curated by ChEMBL | Assay Description Inhibition of human N-terminal MBP-fused NEU4 expressed in Escherichia coli using 4MU-NANA as substrate preincubated for 15 mins followed by substrat... | J Med Chem 61: 1990-2008 (2018) Article DOI: 10.1021/acs.jmedchem.7b01574 BindingDB Entry DOI: 10.7270/Q2XS5XV6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sialidase-4 (Homo sapiens (Human)) | BDBM50330326 ((4S,5R,6R)-5-Acetylamino-4-guanidino-6-((1R,3R)-1,...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 4.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Alberta Curated by ChEMBL | Assay Description Inhibition of MBP-fused recombinant human neuraminidase 4 expressed in Escherichia coli using 4MU-NANA as substrate preincubated for 15 mins followed... | Bioorg Med Chem 26: 5349-5358 (2018) Article DOI: 10.1016/j.bmc.2018.05.035 BindingDB Entry DOI: 10.7270/Q29W0J57 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sialidase-4 (Homo sapiens (Human)) | BDBM50330326 ((4S,5R,6R)-5-Acetylamino-4-guanidino-6-((1R,3R)-1,...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 3.92E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Thammasat University Curated by ChEMBL | Assay Description Inhibition of human Neu4 expressed in HEK293T cells using 4MU-Neu5Ac as substrate incubated for 30 mins by HPLC analysis | J Med Chem 59: 4563-77 (2016) Article DOI: 10.1021/acs.jmedchem.5b01863 BindingDB Entry DOI: 10.7270/Q2QN68QP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sialidase-4 (Homo sapiens (Human)) | BDBM50330326 ((4S,5R,6R)-5-Acetylamino-4-guanidino-6-((1R,3R)-1,...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 4.87E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Miyagi Cancer Center Research Institute Curated by ChEMBL | Assay Description Inhibition of human NEU4 expressed in HEK293 cells by fluorometric high-performance liquid chromatography using 4MU-NeuAc substrate | Antimicrob Agents Chemother 52: 3484-91 (2008) Article DOI: 10.1128/AAC.00344-08 BindingDB Entry DOI: 10.7270/Q2BR8T42 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sialidase-4 (Homo sapiens (Human)) | BDBM50330326 ((4S,5R,6R)-5-Acetylamino-4-guanidino-6-((1R,3R)-1,...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 6.90E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Miyagi Cancer Center Research Institute Curated by ChEMBL | Assay Description Inhibition of human NEU4 expressed in HEK293 cells by fluorometric high-performance liquid chromatography using ganglioside GM3 substrate | Antimicrob Agents Chemother 52: 3484-91 (2008) Article DOI: 10.1128/AAC.00344-08 BindingDB Entry DOI: 10.7270/Q2BR8T42 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sialidase-4 (Homo sapiens (Human)) | BDBM50330326 ((4S,5R,6R)-5-Acetylamino-4-guanidino-6-((1R,3R)-1,...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 1.04E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
Thammasat University Curated by ChEMBL | Assay Description Inhibition of human Neu4 expressed in HEK293T cells using GM3 as substrate incubated for 30 mins by HPLC analysis | J Med Chem 59: 4563-77 (2016) Article DOI: 10.1021/acs.jmedchem.5b01863 BindingDB Entry DOI: 10.7270/Q2QN68QP | |||||||||||
More data for this Ligand-Target Pair |