BindingDB PrimarySearch

Found 6 hits Enz. Inhib. hit(s) with Target = 'Sigma non-opioid intracellular receptor 1' and Ligand = 'BDBM50002218'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Sigma non-opioid intracellular receptor 1 (Mus musculus (Mouse))	BDBM50002218 (2-(1-Cyclopropylmethyl-piperidin-4-yl)-1-(4-fluoro...) Show SMILES Fc1ccc(cc1)C(=O)CC1CCN(CC2CC2)CC1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	PubMed	10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Du Pont Merck Pharmaceutical Company Curated by ChEMBL					Assay Description In vitro binding affinity for the mouse sigma opioid receptor				J Med Chem 35: 4344-61 (1992) BindingDB Entry DOI: 10.7270/Q28P614G
Du Pont Merck Pharmaceutical Company Curated by ChEMBL					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (Homo sapiens (Human))	BDBM50002218 (2-(1-Cyclopropylmethyl-piperidin-4-yl)-1-(4-fluoro...) Show SMILES Fc1ccc(cc1)C(=O)CC1CCN(CC2CC2)CC1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	PubMed	10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
DuPont Merck Pharmaceutical Company Curated by ChEMBL					Assay Description Binding affinity for sigma receptor of guinea pig whole brain using [3H]-SKF- 100047 radioligand				J Med Chem 37: 364-70 (1994) BindingDB Entry DOI: 10.7270/Q2WD416F
DuPont Merck Pharmaceutical Company Curated by ChEMBL					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (Homo sapiens (Human))	BDBM50002218 (2-(1-Cyclopropylmethyl-piperidin-4-yl)-1-(4-fluoro...) Show SMILES Fc1ccc(cc1)C(=O)CC1CCN(CC2CC2)CC1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	PubMed	10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
New York University Curated by ChEMBL					Assay Description Binding affinity against sigma receptor in bovine cerebellum using 2.0 nM [3H]- haloperidol				J Med Chem 36: 3923-8 (1994) BindingDB Entry DOI: 10.7270/Q2H13122
New York University Curated by ChEMBL					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (RAT)	BDBM50002218 (2-(1-Cyclopropylmethyl-piperidin-4-yl)-1-(4-fluoro...) Show SMILES Fc1ccc(cc1)C(=O)CC1CCN(CC2CC2)CC1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2.60	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S Curated by ChEMBL					Assay Description Binding affinity towards sigma receptor binding site 1 using [3H](+)-pentazocine				J Med Chem 38: 1998-2008 (1995) BindingDB Entry DOI: 10.7270/Q2SJ1M8P
H. Lundbeck A/S Curated by ChEMBL					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (RAT)	BDBM50002218 (2-(1-Cyclopropylmethyl-piperidin-4-yl)-1-(4-fluoro...) Show SMILES Fc1ccc(cc1)C(=O)CC1CCN(CC2CC2)CC1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2.60	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S Curated by ChEMBL					Assay Description Compound was evaluated for the binding affinity towards Sigma receptor type 1 using radioligand ([3H]-(+)- Pentazocine) binding assay.				J Med Chem 38: 2009-17 (1995) BindingDB Entry DOI: 10.7270/Q2NS0VKD
H. Lundbeck A/S Curated by ChEMBL					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (RAT)	BDBM50002218 (2-(1-Cyclopropylmethyl-piperidin-4-yl)-1-(4-fluoro...) Show SMILES Fc1ccc(cc1)C(=O)CC1CCN(CC2CC2)CC1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	PubMed	n/a	n/a	23	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S Curated by ChEMBL					Assay Description Binding affinity towards Sigma receptor site 2 in rat brain using [3H]DTG as radioligand				J Med Chem 38: 2009-17 (1995) BindingDB Entry DOI: 10.7270/Q2NS0VKD
H. Lundbeck A/S Curated by ChEMBL					More data for this Ligand-Target Pair