Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Smoothened homolog (Homo sapiens (Human)) | BDBM50324671 (CHEMBL1221984 | Purmorphamine) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Stanford University School of Medicine Curated by ChEMBL | Assay Description Inhibition of BODIPY-cyclopamine binding to Smo expressed in HEK293T cells after 1 hr by fluorescence microscopy | Nat Chem Biol 2: 29-30 (2006) Article DOI: 10.1038/nchembio753 BindingDB Entry DOI: 10.7270/Q2736R40 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Smoothened homolog (Homo sapiens (Human)) | BDBM50324671 (CHEMBL1221984 | Purmorphamine) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents | n/a | n/a | n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Smoothened homolog (Mus musculus) | BDBM50324671 (CHEMBL1221984 | Purmorphamine) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | n/a | n/a | 800 | n/a | n/a | n/a | n/a |
Universit£ di Siena Curated by ChEMBL | Assay Description Activity at Smo in mouse C3H10T1/2 cells assessed as induction of cell differentiation into osteoblast incubated for 6 days by alkaline phosphatase a... | Eur J Med Chem 121: 747-757 (2016) Article DOI: 10.1016/j.ejmech.2016.05.062 BindingDB Entry DOI: 10.7270/Q2W66NQ9 | |||||||||||
More data for this Ligand-Target Pair |