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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Sodium/calcium exchanger 1' and Ligand = 'BDBM140928'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Sodium/calcium exchanger 1


(Homo sapiens (Human))		BDBM140928
PNG
(US8912224, 366)
Show SMILES COc1c(F)cccc1C1CCc2cc(Oc3ncc(s3)C(=O)NCc3ccno3)ccc2O1
Show InChI InChI=1S/C24H20FN3O5S/c1-30-22-17(3-2-4-18(22)25)20-7-5-14-11-15(6-8-19(14)32-20)31-24-27-13-21(34-24)23(29)26-12-16-9-10-28-33-16/h2-4,6,8-11,13,20H,5,7,12H2,1H3,(H,26,29)
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Similars
US Patent
n/an/a 180n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The assay is based on the monitoring of intracellular Ca2+concentrations using the calcium-sensitive dye Fluo-4. CHO cells expressing NCX1 were loade...

US Patent US8912224 (2014)


BindingDB Entry DOI: 10.7270/Q22F7M52
More data for this
Ligand-Target Pair