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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Sodium/glucose cotransporter 2' and Ligand = 'BDBM50239263'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50239263
PNG
(CHEMBL4063778)
Show SMILES CO[C@@]12CO[C@@](O1)([C@H](O)[C@@H](O)[C@@H]2O)c1ccc(Cl)c(Cc2ccc(O[C@H]3CCOC3)cc2)c1 |r|
Show InChI InChI=1S/C24H27ClO8/c1-29-23-13-31-24(33-23,22(28)20(26)21(23)27)16-4-7-19(25)15(11-16)10-14-2-5-17(6-3-14)32-18-8-9-30-12-18/h2-7,11,18,20-22,26-28H,8-10,12-13H2,1H3/t18-,20-,21-,22+,23-,24-/m0/s1
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PC sid
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Similars
Article
PubMed
n/an/a 5.90n/an/an/an/an/an/a



Haisco Pharmaceuticals Group Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as decrease in uptake of [14C]AMG after 120 mins by TopCount method

J Med Chem 60: 4173-4184 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01818
BindingDB Entry DOI: 10.7270/Q2W37ZFS
More data for this
Ligand-Target Pair