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Found 1 hit Enz. Inhib. hit(s) with Target = 'Sodium/glucose cotransporter 2' and Ligand = 'BDBM50239267'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50239267
PNG
(CHEMBL4062100)
Show SMILES CCOc1ccc(Cc2cc(ccc2Cl)[C@]23OC[C@](OCCO)(O2)[C@@H](O)[C@H](O)[C@H]3O)cc1 |r|
Show InChI InChI=1S/C23H27ClO8/c1-2-29-17-6-3-14(4-7-17)11-15-12-16(5-8-18(15)24)23-21(28)19(26)20(27)22(32-23,13-31-23)30-10-9-25/h3-8,12,19-21,25-28H,2,9-11,13H2,1H3/t19-,20-,21+,22-,23-/m0/s1
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Article
PubMed
n/an/a 31n/an/an/an/an/an/a



Haisco Pharmaceuticals Group Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as decrease in uptake of [14C]AMG after 120 mins by TopCount method

J Med Chem 60: 4173-4184 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01818
BindingDB Entry DOI: 10.7270/Q2W37ZFS
More data for this
Ligand-Target Pair