BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Sodium/glucose cotransporter 2' and Ligand = 'BDBM50265235'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50265235
PNG
(24-[({6-[4-({2-chloro-5-[(2S,3R,4R,5S,6R)-3,4,5-tr...)
Show SMILES CC1(C)C2=C3C=C4C(CC[N+]5=C4C(C)(C)c4cc(ccc54)S([O-])(=O)=O)OC3CCN2c2ccc(CC(=O)NCCCCCCOc3ccc(Cc4cc(ccc4Cl)[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)cc3)cc12 |r,c:3,5,10|
Show InChI InChI=1S/C56H64ClN3O11S/c1-55(2)40-26-33(11-17-43(40)59-22-19-45-38(53(55)59)30-39-46(70-45)20-23-60-44-18-15-37(72(66,67)68)29-41(44)56(3,4)54(39)60)27-48(62)58-21-7-5-6-8-24-69-36-13-9-32(10-14-36)25-35-28-34(12-16-42(35)57)52-51(65)50(64)49(63)47(31-61)71-52/h9-18,26,28-30,45-47,49-52,61,63-65H,5-8,19-25,27,31H2,1-4H3,(H-,58,62,66,67,68)/t45?,46?,47-,49-,50+,51-,52+/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 102n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake by fluorescence polarization assay

Bioorg Med Chem Lett 18: 4944-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.036
BindingDB Entry DOI: 10.7270/Q27944J7
More data for this
Ligand-Target Pair