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Found 1 hit Enz. Inhib. hit(s) with Target = 'Sodium/glucose cotransporter 2' and Ligand = 'BDBM50344665'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50344665
PNG
(6,8-dichloro-4-((5-((4-chlorophenoxy)methyl)-4-(3,...)
Show SMILES FC(F)(F)CCn1c(COc2ccc(Cl)cc2)nnc1CN1C(=O)COc2c(Cl)cc(Cl)cc12
Show InChI InChI=1S/C21H16Cl3F3N4O3/c22-12-1-3-14(4-2-12)33-10-18-29-28-17(30(18)6-5-21(25,26)27)9-31-16-8-13(23)7-15(24)20(16)34-11-19(31)32/h1-4,7-8H,5-6,9-11H2
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Similars
Article
PubMed
n/an/a 73n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...

Bioorg Med Chem Lett 21: 3774-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.053
BindingDB Entry DOI: 10.7270/Q2KK9C32
More data for this
Ligand-Target Pair